Thermosensitive Behavior Defines the Features of Poly(N-isopropylacrylamide)/Magnetite Nanoparticles for Cancer Management

This paper reports the preparation and characterization of thermosensitive poly(N-isopropylacrylamide) (PNIPAM)/magnetite nanoparticles in various conditions. The nanoprecipitation conditions address impact temperature on PNIPAM/magnetite nanoparticle features due to character PNIPAM. Hybrid with desired (size, size distribution, agglomeration, release profile) are prepared by non-solvent (acetone) at temperatures. These targeted as nanocarriers deliver doxorubicin breast cancer cells. Therefore, three temperatures, below LCST (lower critical solution temperature), around LCST, above were chosen main parameters within nanoprecipitation. Besides temperature, another major parameter drives nanoparticles’ features: polymer concentration. In this regard, two variable used study characteristics developed hybrid nanoparticles. After preparation, subjected morphological distribution investigation SEM DLS. loading measurements also performed reveal behavior Finally, unloaded loaded biologically assessed a cells line (MCF7) terms biocompatibility, cell viability, morphology.